both a GLP-1 agonist (Byetta, etc) and DPP-4 inhibitor (Januvia, etc) for type 2 diabetes

August 2012

Is it okay to give patients both a GLP-1 agonist (Byetta, etc) and DPP-4 inhibitor (Januvia, etc) for type 2 diabetes?

This is sometimes tried if patients need combo therapy and they want to avoid weight gain or hypoglycemia from other meds.

GLP-1 agonists mimic incretin hormones...while DPP-4 inhibitors, or "gliptins," prevent the breakdown of endogenous incretins.

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